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(Last updated : 2025-06-06 09:34:32)   KURIHARA YUKIKO    Faculty of Nutrition    Professor

■ Education 1. 1982/04～1988/03 Faculty of Medicine, Chiba University, Graduated, 2. 1994/12/21 Degree Acquisition The University of Tokyo,

■ Career 1. 1988/06～1990/05 The University of Tokyo Hospital Expert 2. 1990/06～1995/03 National Institute of Health and Nutrition Researher Postdoc 3. 1995/04～1998/03 The University of Tokyo Hospital / Japan Society for the Promorion of Sciemce 4. 1998/04～2002/04 The University of Tokyo Hospital / University of Tsukuba PMDA Researher Postdoc 5. 2002/05～2008/03 University of Tokyo Medical Science Graduate Program Physiological Chemistry and Metabolism Assistant Professor 6. 2008/04～2023/04 University of Tokyo Medical Science Graduate Program Physiological Chemistry and Metabolism 7. 2023/04～2024/03 University of Tokyo Medical Science Graduate Program Physiological Chemistry and Metabolism Associate Professor 8. 2024/04～ Kagawa Nutrition University Faculty of Nutrition Professor 9. 2024/04～ Isotope Science Center,The Univesity of Tokyo 10. 2024/08～ International Researh Center for Medical Sciences 5 display All display(10)

■ Courses Previously Taught 1. Anatomical physiology（Kagawa Nutrition University） 2. biochemistry（The University of Tokyo） 3. Health promotion sports medicine（Kagawa Nutrition University） 4. Imaging examination（Kagawa Nutrition University） 5. nutritional physiology（Kagawa Nutrition University） 6. Physiological function testing（Kagawa Nutrition University） 5件表示 全件表示(6件)

■ Publications 1. Journal Articles Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.  (Collaboration)  1994/04 2. Journal Articles Role of endothelin-1 in stress response in the central nervous system.  (Collaboration)  2000 3. Journal Articles An endothelin-1 switch specifies maxillomandibular identity.  (Collaboration)  2008 4. Journal Articles Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1  (Collaboration)  2008 5. Journal Articles Mandibulofacial dysostosis with alopecia results from gain-of-ETAR function via allosteric effects on ligand binding.  (Collaboration)  2023/02 6. Journal Articles Biallelic truncating variants in VGLL2 cause syngnathia in humans.  (Collaboration)  2023 7. Journal Articles Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting  (Collaboration)  2023 8. Journal Articles Semaphorin3E-PlexinD1 signaling is required for coronary artery and lymphatic vessel development, with clinical implications in myocardial recovery.  (Collaboration)  2021 9. Journal Articles Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells.  (Collaboration)  2018 10. Journal Articles Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system.  (Collaboration)  2017 11. Journal Articles Postotic and preotic cranial neural crest cells differently contribute to thyroid development.  (Collaboration)  2016 12. Journal Articles Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.  (Collaboration)  2015 13. Journal Articles Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.  (Collaboration)  2015 14. Journal Articles Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem.  (Collaboration)  2015 15. Journal Articles Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia.  (Collaboration)  2015 16. Journal Articles Calpain-6 deficiency promotes skeletal muscle development and regeneration.  (Collaboration)  2013 17. Journal Articles Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.  (Collaboration)  2013 18. Journal Articles Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling.  (Collaboration)  2012 19. Journal Articles Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement.  (Collaboration)  2011 20. Journal Articles Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice.  (Collaboration)  2011 21. Journal Articles Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.  (Collaboration)  2011 22. Journal Articles Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney.  (Collaboration)  2011 23. Journal Articles Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field, with a later implication of this signaling pathway in chamber myocardium formation.  (Collaboration)  2010 24. Journal Articles Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst.  (Collaboration)  2010 25. Journal Articles Evolving maps in craniofacial development.  (Collaboration)  2010 26. Journal Articles Jaw muscularization requires Dlx expression by cranial neural crest cells.  (Collaboration)  2010 27. Journal Articles Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.  (Collaboration)  2010 28. Journal Articles AMPK activation increases phosphorylation of GSK3β and thereby reduces CRE transcriptional activity and PEPCK-C gene expression in the liver.  (Collaboration)  2008 29. Journal Articles Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.  (Collaboration)  2008 30. Journal Articles Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide.  (Collaboration)  2008 31. Journal Articles Recombinase-mediated cassette exchange revealed the selective use of Gq/G11-dependent and -independent endothelin-1/endothelin type-A receptor signaling in pharyngeal arch development.  (Collaboration)  2008 32. Journal Articles Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis.  (Collaboration)  2008 33. Journal Articles Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis.  (Collaboration)  2008 34. Journal Articles Calcitonin gene-related peptide mediates acid-induced lung injury in mice.  (Collaboration)  2007 35. Journal Articles Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.  (Collaboration)  2007 36. Journal Articles Molecular dynamics of retinoic acid-induced craniofacial malformations: implications for the origin of gnathostome jaws.  (Collaboration)  2007 37. Journal Articles Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis.  (Collaboration)  2007 38. Journal Articles Transcriptional activity of Pax3 is co-activated by TAZ.  (Collaboration)  2006 39. Journal Articles Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis.  (Collaboration)  2005 40. Journal Articles Endothelin-1 regulates the dorsoventral branchial arch patterning in mice.  (Collaboration)  2004 41. Journal Articles Temporal requirement of signaling cascade involving endothelin-1/endothelin A receptor in branchial arch development.  (Collaboration)  2004 42. Journal Articles Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.  (Collaboration)  2003 43. Journal Articles Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.  (Collaboration)  2003 44. Journal Articles Targeted disruption of adrenomedullin and aCGRP genes reveals their distinct biological roles.  (Collaboration)  2003 45. Journal Articles Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.  (Collaboration)  2002 46. Journal Articles Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.  (Collaboration)  2002 47. Journal Articles Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice.  (Collaboration)  2002 48. Journal Articles Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after baloon injury.  (Collaboration)  2001 49. Journal Articles Elevated sympathetic nervous activity in mice deficient in aCGRP.  (Collaboration)  2001 50. Journal Articles Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.  (Collaboration)  2001 51. Journal Articles Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.  (Collaboration)  2001 52. Journal Articles ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility and organ morphology and function.  (Collaboration)  2000 53. Journal Articles Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases.  (Collaboration)  2000 54. Journal Articles Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.  (Collaboration)  2000 55. Journal Articles Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo.  (Collaboration)  2000 56. Journal Articles Molecular cloning of the bovine MYOC and induction of its expression in trabecular meshwork cells.  (Collaboration)  2000 57. Journal Articles Role of endothelin-1 in stress response in the central nervous system.  (Collaboration)  2000 58. Journal Articles D919G polymorphism of the methionine synthase gene. Association with homocysteine metabolism and late-onset vascular diseases in the Japanese population.  (Collaboration)  1999 59. Journal Articles Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice.  (Collaboration)  1999 60. Journal Articles Endothelin and neural crest development.  (Collaboration)  1999 61. Journal Articles Endothelin in the central control of cardiovascular and respiratory functions.  (Collaboration)  1999 62. Journal Articles Responses of blood pressure and neurohumoral factors to high salt loading in endothelin-1 knockout mice.  (Collaboration)  1999 63. Journal Articles A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection  (Collaboration)  1998/03 64. Journal Articles A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural crest-derived branchial arch mesenchyme.  (Collaboration)  1998 65. Journal Articles Airway hyperresponsiveness to methacholine in mutant mice deficient in endothelin-1.  (Collaboration)  1998 66. Journal Articles Cardiac sarcoidosis.  (Collaboration)  1998 67. Journal Articles Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization.  (Collaboration)  1998 68. Journal Articles Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke in Japanese.  (Collaboration)  1998 69. Journal Articles Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice.  (Collaboration)  1998 70. Journal Articles Systemic and renal response to salt loading in endothelin-1 knockout mice.  (Collaboration)  1998 71. Journal Articles Upregulation of endothelin-1 and adrenomedullin gene expression in mouse endotoxin shock model.  (Collaboration)  1998 72. Journal Articles A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.  (Collaboration)  1997 73. Journal Articles Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease.  (Collaboration)  1997 74. Journal Articles Germ-line contribution of embryonic stem cells in chimeric mice: influence of karyotype and in vitro differentiation ability.  (Collaboration)  1997 75. Journal Articles Physiological role of brain endothelin in the central autonomic control: from neuron to knockout mice.  (Collaboration)  1997 76. Journal Articles The macrophage scavenger receptor type A is expressed by activated Macrophages and protects the host against lethal endotoxic shock.  (Collaboration)  1997 77. Journal Articles The multiple roles of macrophage scavenger receptors (MSR) in vivo: Resistance to atherosclerosis and susceptibility to infection in MSR knockout mice.  (Collaboration)  1997 78. Journal Articles The role of endothelin-1 in cardiovascular development.  (Collaboration)  1997 79. Journal Articles Endothelin-1 regulates normal cardiovascular development and cardiac cellular hypertrophy.  (Collaboration)  1996 80. Journal Articles Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1.  (Collaboration)  1996 81. Journal Articles Multiple roles for endothelin 3 in melanocyte development: Regulation of progenitor number and stimulation of differentiation.  (Collaboration)  1996 82. Journal Articles Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.  (Collaboration)  1996 83. Journal Articles Sequence analysis, chromosomal location and developmental expression of the mouse preproendothelin-1 gene.  (Collaboration)  1996 84. Journal Articles Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.  (Collaboration)  1995 85. Journal Articles Gene expression of endothelin isoforms and receptors in endothelin-1-knockout mice.  (Collaboration)  1995 86. Journal Articles Impaired development of the thyroid and thymus in endothelin-1 knockout mice.  (Collaboration)  1995 87. Journal Articles Power spectral analysis of arterial blood pressure in mice: comparison between normal and endothelin-1 gene knocked out mice.  (Collaboration)  1995 88. Journal Articles Role of endothelin in central cardiorespiratory control: modern and classical approaches.  (Collaboration)  1995 89. Journal Articles Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.  (Collaboration)  1995 90. Journal Articles Establishment of mice carrying the mutant endothelin-1 gene by gene targeting  (Collaboration)  1994 91. Journal Articles Isolation and characterization of vascular endothelial cells derived from mice lacking endothelin-1.  (Collaboration)  1994 92. Journal Articles Production of a germ-line chimera by coculture of zona-free embryos with frozen-thawed embryonic stem cells.  (Collaboration)  1994 93. Journal Articles Renal endothelin and hypertension - reply.  (Collaboration)  1994 94. Journal Articles Stenotic bicuspid aortic valve associated with a ventricular septal defect in an adult presenting with congestive heart failure: a rare observation.  (Collaboration)  1994 95. Journal Articles Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors.  (Collaboration)  1993 96. Journal Articles Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene.  (Collaboration)  1993 97. Journal Articles Macrophage scavenger receptors.  (Collaboration)  1991 5 display All display(97)

■ Memberships 1. The Molecular Biology Society of Japan

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