ウスイ　テルユキ   Teruyuki USUI
  臼井　照幸
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2004/01
形態種別 研究論文（学術雑誌）
標題 Detection and Determination of Glyceraldehyde-derived Advanced GlycationEnd Product
執筆形態 共著
掲載誌名 BioFactors
出版社・発行元 ISO Press
巻・号・頁 21,pp.391-394
著者・共著者 Teruyuki USUI,Kazuhito SHIMOHIRA,Hirohito WATANABE,Fumitaka HAYASE
概要 GLAP, glyceraldehyde-derived pyridinium-type advanced glycation end product (AGE), formed by glyceraldehyde-related glycation, was identified in the plasma protein and the tail tendon collagen of streptozotocin (STZ)-induced diabetic rats. It was detected in the plasma protein and the collagen in diabetic rats by LC-MS and LC-MS/MS analysis, but was not detected in normal rats. In addition, GLAP was formed from glyceraldehyde-3-phosphate (GA3P) with lysine as well as glyceraldehyde (GLA) with lysine in vitro. Accordingly, it is suggested that an increase in the GLAP level reflects an increase in the GLA level and the GA3P level. GLAP might be a biomarker for reduced activity of the glyceraldehyde-related enzymes in the metabolic diseases such as diabetic complications.