ウスイ　テルユキ   Teruyuki USUI
  臼井　照幸
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2007/09
形態種別 研究論文（学術雑誌）
標題 Determination of glyceraldehyde formed in glucose degradation and glycation
執筆形態 共著
掲載誌名 Bioscience Biotechnology, and Biochemistry
巻・号・頁 71,pp.2162-2168
著者・共著者 Teruyuki USUI,Miku YOSHINO,Hirohito WATANABE,Fumitaka HAYASE
概要 Glyceraldehyde (GLA) was determined in glucose degradation and glycation. GLA was detected as a decahydroacridine-1,8-dione derivative on reversed phase HPLC using cyclohexane-1,3-dione derivatizing reagent. The glucose-derived GLA level was higher than the glycation-derived GLA level, because GLA was converted to intermediates and advanced glycation end products (AGE) in glycation. GLA was also generated from 3-deoxyglucosone and glucosone as intermediates of glucose degradation and glycation. This study suggests that glyceraldehyde is generated by hyperglycemia in diabetes, and that it is also formed in medicines such as peritoneal dialysis solution.