ウスイ　テルユキ   Teruyuki USUI
  臼井　照幸
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2007/10
形態種別 研究論文（学術雑誌）
標題 Identification and determination of α-dicarbonyl compounds formed in the degradation of sugars
執筆形態 共著
掲載誌名 Bioscience Biotechnology, and Biochemistry
巻・号・頁 71,pp.2465-2472
著者・共著者 Teruyuki USUI,Satoshi YANAGISAWA,Mio OHGUCHI,Miku YOSHINO,Risa KAWABATA,Junko KISHIMOTO,Yumi ARAI,Kaoru AIDA,Hirohito WATANABE,Fumitaka HAYASE
概要 The α-dicarbonyl compounds formed in the degradation of glucose and fructose were analyzed by HPLC using 2,3-diaminonaphthalene as derivatizing reagent, and identified as glucosone (GLUCO), 3-deoxyglucosone (3DG), 3-deoxyxylosone (3DX), tetrosone (TSO), triosone (TRIO), 3-deoxytetrosone (3DT), glyoxal (GO), and methylglyoxal (MGO). The results suggest that α-dicarbonyl compounds were formed from glucose via non-oxidative 3-deoxyglucosone formation and oxidative glucosone formation in glucose degradation. In addition, TRIO, GO, and MGO were also formed from glyceraldehyde as intermediate. The α-dicarbonyl compounds might be formed from glucose via these pathways in diabetes.