ウスイ テルユキ   Teruyuki USUI
  臼井 照幸
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2008/02
形態種別 研究論文(学術雑誌)
標題 Formation of argpyrimidine in glyceraldehyde-related glycation
執筆形態 共著
掲載誌名 Bioscience Biotechnology, and Biochemistry
巻・号・頁 71,pp.2465-2472
著者・共著者 Teruyuki USUI,Mio Ohguchi,Hirohito WATANABE,Fumitaka HAYASE
概要 Three major glyceraldehyde-related advanced glycation end products (AGEs) were formed from a mixture of Nα-acetyllysine, Nα-acetylarginine, and glyceraldehyde. Two of the compounds were MG-H1 and GLAP, as previously reported, and the other compound was identified as Nα-acetyl-Nδ-(5-hydroxy-4,6-dimethyl-pyrimidin-2-yl)-ornithine, argpyrimidine (APN). APN is a modification product of arginine residue, but it did not form from glyceraldehyde with arginine residue. The coexistence of lysine residue was necessary to APN formation.