アカイ ショウジ   Akai Shoji
  赤井 昭二
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2005/10
形態種別 研究論文
査読 査読あり
標題 Convenient construction of a variety of glycosidic linkages using a universal glucosyl donor
執筆形態 共著
掲載誌名 Tetrahedron Lett.
掲載区分国外
出版社・発行元 Elsevier
巻・号・頁 46(43),pp.7411-7414
著者・共著者 K. Sato, S. Akai, K. Sakai, M. Kojima, H. Murakami, T. Idoji
概要 A universal glucosyl donor. The selectively protected universal glucosyl donor I was synthesized in 36% yield from D- glucose (eight steps). The donor I undergoes glycosidation with a primary carbohydrate alc. II to give disaccharide having a 1,2-cis-alpha-glycosidic linkage in 90% yield. The construction of the corresponding 1,2-trans-alpha-glycosidic linkage was performed in 68% yield. A similar glycosylation of the 2-O-(N-phenylcarbamoyl)-glucosyl donor III (Car = N-phenyl-carbamoyl) derived from 8 with II gave disaccharide having a 1,2-trans-β-glycosidic linkage in 75% yield. The construction of the corresponding 1,2-cis-β-linkage was performed in 53% yield (three steps).