アカイ ショウジ   Akai Shoji
  赤井 昭二
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2008/03
形態種別 研究論文
査読 査読あり
標題 Stereoselective and Efficient Total Synthesis of Optically Active Tetrodotoxin from D-Glucose
執筆形態 共著
掲載誌名 J. Org. Chem.
掲載区分国外
出版社・発行元 America Chemical Society Publications
巻・号・頁 73(4),pp.1234-1242
著者・共著者 K. Sato, S. Akai, H. Shoji, N. Sugita, S. Yoshida, Y. Nagai, K. Suzuki, Y. Nakamura, Y. Kajihara, M. Funabashi, J. Yoshimura
概要 A stereoselective and efficient total synthesis of optically active tetrodotoxin (TTX) is described. A polyfunctionalized key
cyclitol compd. contg. branched-chains for the synthesis of TTX was prepd. from D-glucose employing the Henry reaction (Nitro aldol reaction) as the key transformation. Stereoselective construction of the -azido-aldehyde branched-chain was achieved via the key spiro alpha-chloroepoxide intermediate.
Most-Accessed Articles_ January-March 2008 - Journal of Organic Chemistry