アカイ ショウジ   Akai Shoji
  赤井 昭二
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2008/07
形態種別 研究論文
査読 査読あり
標題 Thioester-assisted alpha-sialylation reaction
執筆形態 共著
掲載誌名 Tetrahedron Lett.
掲載区分国外
出版社・発行元 Elsevier
巻・号・頁 49(43),pp.5111-5114
著者・共著者 S. Hanashima, S. Akai, K. Sato
概要 alpha-Selective sialylation reactions were carried out using novel sialic acid building blocks that possess a thioester auxiliary. In contrast to other arylthio- and benzylthioester derivs., sialyl phosphite I was employed as the alpha-selective building block, and was reacted with various primary alcs., including the C6-OH group of galactose and glucose, with moderate to excellent α-selectivities to give disaccharides, e.g. II, or glycosides. For C3-OH of the galactose, 4,6-di-O-benzylgalactal afforded desired alpha-linkage with excellent selectivity.