アカイ ショウジ   Akai Shoji
  赤井 昭二
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2010/03
形態種別 研究論文
査読 査読あり
標題 Total Synthesis of (-)-Tetrodotoxin from D-Glucose:A New Route to Multi-Functionalized Cyclitol Employing the Ferrier(II) Reaction toward (-)-Tetrodotoxin
執筆形態 共著
掲載誌名 Bull. Chem. Soc. Jpn.
掲載区分国外
出版社・発行元 Bulletin of the Chemical Society of Japan
巻・号・頁 83(3),pp.279-287
著者・共著者 S. Akai, H. Seki, N.; Sugita, T. Kogure, N. Nishizawa, K. Suzuki, Y. Nakamura, Y. Kajihara, J. Yoshimura, K. Sato
概要 Total synthesis of (-​)​-​tetrodotoxin (TTX) from D-​glucose is described. As a crit. transformation step for synthesizing TTX, a key multi-​functionalized cyclitol was prepd. from D-​glucose employing the Ferrier(II) reaction. Stereospecific introduction of three functionalized branched chains were achieved via Peterson olefination and spiro α-​chloroepoxidn. of the corresponding carbonyl derivs.