アカイ ショウジ   Akai Shoji
  赤井 昭二
   所属   栄養学部
   職種   教授
言語種別 英語
発行・発表の年月 2012/01
形態種別 研究論文
査読 査読あり
標題 Scope and limitations of a modified Hantzsch reaction for the synthesis of oxazole-dehydroamino acid derivatives from dehydroamino acid amides
執筆形態 共著
掲載誌名 Heterocycles
掲載区分国外
出版社・発行元 The Japan Institute of Heterocyclic Chemistry
巻・号・頁 85(2),pp.313-331
著者・共著者 A. Nagaya, Y. Yamagishi, Y. Yonezawa, S. Akai, C. Shin, K. Sato
概要 A variety of oxazole derivs. that possess an α,​β-​unsatd. substituent at the 2-​position were conveniently synthesized in good yields via a Hantzsch-​type reaction between dehydroamino acid amides and β-​bromopyruvate derivs. Furthermore, oxazoles with substituents at the 2- and 5-​positions were also obtained in good yields using the corresponding β-​substituted β-​bromopyruvate derivs. A revised reaction mechanism to explain the enhanced reactivity of dehydroamino acid amides for the Hantzsch-​oxazole-​type reaction is presented.