|標題||Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years.|
|掲載誌名||Renal Replacement Therapy|
|著者・共著者||Kaori Sakamoto, Yoshihiko Kanno, Mami Hiraoka, Matsuhiko Hayashi, Yoshiko Kontai, Yasuo Kagawa|
|概要||Methods:Seventy-eight of Japanese patients receiving HD more than 30 years were enrolled. Their daily lifestyle and activity were evaluated with diet history questionnaires (DHQ), geriatric nutritional risk index (GNRI), and basic activity of daily living (BADL) scores. MTHFR C677T was genotyped by PCR-restriction fragment length polymorphism (RFLP).
Conclusion:Although the frequency of TT genotype was higher than healthy population, our patients showed longer survival with high QOL and nutritional status. It is suggested that the proper lifestyle might overcome the genetic risk factors in patients receiving HD.