ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1997
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 The potent inhibition of Vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets.
執筆形態 共著
掲載誌名 Biol. Pharm. Bull.
巻・号・頁 20(6),pp.625-631
総ページ数 null
著者・共著者 Horie S, Yamada M, Satoh M, Noritake S, Hiraishi S, Kizaki K, Kurusu O, Nakahara T, Ishii H, Kazama M
概要 The inhibitory effects of vapiprost hydrochloride (vapiprost), a novel thromboxane A2 receptor antagonist, on platelet aggregation and ATP release were studied. In vitro experiments with human platelet, vapiprost inhibited the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA). Vapiprost did not inhibit the primary aggregation or ATP release of human platelets stimulated with ADP, epinephrine or platelet activating factor (PAF), but inhibited the secondary aggregation stimulated with those agonists. In ex vivo experiments with guinea pigs which received a single oral dose of vapiprost, the agent demonstrated strong inhibition of ATP release from platelets stimulated with U-46619, collagen or AA. These inhibitory effects were observed within 30 min and sustained for 24 h at a single dosage of 5 mg/kg of vapiprost.