ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1984
形態種別 研究論文(学術雑誌)
標題 The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma.
執筆形態 共著
掲載誌名 Thromb Res.
巻・号・頁 34(5),pp.447-55
総ページ数 null
著者・共著者 Ishii H, Hiraishi S, Kuboki M, Sugiura T, Waku K, Kazama M.
概要 Rabbits were fed with 1% cholesterol-containing standard diet for 1 to 3 months. The arachidonic acid (AA)-induced aggregation of the platelet-rich plasma (PRP) was accelerated by substitution of hypercholesterolemic plasma. The incorporation of 14C-AA into thromboxane B2 in platelets was increased in hypercholesterolemic rabbits as compared with those of the control. Analysis of the fatty acid compositions of phospholipids and total lipids of hypercholesterolemic rabbits revealed an increase in AA of platelets and plasma, and a decrease in docosahexaenoic acid (DHA) in plasma. The AA/DHA ratio of plasma increased dependently on the period of feeding with the high cholesterol diet, and the increase in the ratio was parallel with the acceleration of platelet aggregation by AA in PRP.