ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1990
形態種別 研究論文(学術雑誌)
標題 Elevation of plasma thrombomodulin level in diabetic patients with early diabetic nephropathy.
執筆形態 共著
掲載誌名 Diabetes
巻・号・頁 39(8),pp.983-988
総ページ数 null
著者・共著者 Iwashima Y, Sato T, Watanabe K, Ooshima E, Hiraishi S, Ishii H, Kazama M, Makino I
概要 Thrombomodulin (TM) has been found in human plasma; however, its clinical significance is not known. In this study, fasting plasma TM concentrations in 67 diabetic patients with different degrees of albuminuria and 34 age- and sex-matched healthy subjects were investigated by use of a one-step sandwich enzyme immunoassay. The patients were divided into three groups according to the first morning urinary concentrations of albumin: group 1, less than 30 micrograms/ml (normoalbuminuria); group 2, 30-140 micrograms/ml (microalbuminuria); group 3, greater than 140 micrograms/ml (clinical nephropathy). There was no significant difference in plasma TM level between the control group and group 1 ; however, plasma TM concentrations in group 2 and group 3 increased significantly compared with those in the control group and group 1, respectively.