ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1990
形態種別 研究論文(学術雑誌)
標題 Plasma thrombomodulin levels as an indicator of vascular injury caused by cyclosporine nephrotoxicity.
執筆形態 共著
掲載誌名 Transplantation
巻・号・頁 50,pp.1066-1069
総ページ数 null
著者・共著者 Yoshida M, Kozaki M, Kaji N, Tamaki T, Hiraishi S, Ishii H, Kazama M, Fukutomi K
概要 We measured factor VIII-related antigen (VIII-RAG) and thrombomodulin (TM) in plasma in an attempt to differentiate between chronic renal rejection (CR) snd cyclosporine (Cs) A nephrotoxicity in patiants who developed a gradual deterioration of renal function 6 months or longer after renal transplantation. It was not different in plasma VIII-RAG between CsA-treated and CsA-untreated patients, wereas an increased plasma TM level was found in CsA-only-treated patients. In particular, CsA-treated patients with serum creatinine in accompanied by severe pathological vascular lesions and patients with CsA nephrotoxicity showed a remarkably high level of TM in plasma. We demonstrated that an increase in TM plasma levels precedes an elevated serum creatinine in patients with CsA nephrotoxicity.