ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1991
形態種別 研究論文(学術雑誌)
標題 Increased thrombomodulin values in plasma of diabetic men with microangiopathy.
執筆形態 共著
掲載誌名 Clinical Chemistry
巻・号・頁 37(2),pp.269-272
総ページ数 null
著者・共著者 Tanaka A, Ishii H, Hiraishi S, Kazama M, Maezawa H
概要 To study the significance of plasma thrombomodulin (TM) values in diabetes mellitus, we determined plasma TM in 34 patients with non-insulin-dependent diabetes mellitus (NIDDM) men, mean age 54 (SE 2) years. Plasma TM was determined by an enzyme immunoassay with anti-TM monoclonal antibodies. The plasma TM values were significantly greater in NIDDM patients with nephropathy than in patients without nephropathy. Also, a significant positive correlation was noted between the concentration of plasma TM and serum creatinine. The plasma TM values of the patients with retinopathy were significantly greater than the values of those without it. Furthermore, we noted a significant positive correlation between plasma TM and the severity of diabetic retinopathy as graded by Scott's classification. These results suggest a close relationship between TM and diabetic microangiopathy.