ヒライシ サユリ   
  平石 さゆり
   所属   栄養科学研究所
   職種   専任講師
言語種別 英語
発行・発表の年月 1992
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 Changes in plasma thrombomodulin antigen in rabbit developing endotoxin-induced dissminated intravascular coagulation and the effect of heparin.
執筆形態 共著
掲載誌名 Thromb. Res.
巻・号・頁 65,pp.593-604
総ページ数 null
著者・共著者 Uchiyama H, Ohtani H, Hiraishi S, Horie S, Ishii H, Kazama M
概要 When disseminated intravascular coagulation (DIC) was induced by intravenous infusion of endotoxin into rabbits, the TM antigen level in plasma was elevated to about 1.5 times of the control value. Elevation of the antigen level and disappearance of the 94 kd subspecies caused by infusion of endotoxin were reduced by simultaneous infusion of heparin. Addition of leukocytes stimulated with endotoxin plus FMLP to cultured endothelial cells induced release of TM antigen to the medium accompanying cell injury as measured by 51Cr release, which was prevented by treatment with heparin. It was suggested that the increase in plasma TM antigen level in parallel with the generation of DIC reflected endothelial injury of rabbits, and that the elevation of TM antigen and the endothelial cell injury were prevented by heparin treatment.